ǂan ǂobservational study
Maximilian J Hochmair (Author),
Alessandro Morabito (Author),
Desiree Hao (Author),
Cheng-Ta Yang (Author),
Ross A Soo (Author),
James C-H Yang (Author),
Rasim Gucalp (Author),
Balazs Halmos (Author),
Lara Wang (Author),
Amanda Golembesky (Author),
Angela Märten (Author),
Tanja Čufer (Author)
Abstract
Aim: To assess outcomes in patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer receiving sequential afatinib and osimertinib in a real-world clinical setting. Materials & methods: In this retrospective, observational, multicenter study, patients (n = 204) had T790M-positive disease following first-line afatinib and started osimertinib treatment [>/=]10 months prior to data entry. Primary outcome was time on treatment. Results: Overall median time on treatment was 27.6 months (90% CI: 25.9-31.3), 30.3 months (90% CI: 27.6-44.5) in Del19-positive patients and 46.7 months (90% CI: 26.8-not reached) in Asians. The 2-year overall survival was 78.9%. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib facilitates prolonged, chemotherapy-free treatment in patients with T790M acquired resistance, and is a potentially attractive strategy, especially for Del19-positive tumors.
Keywords
non-small-cell lung cancer;afatinib;osimertinib;epidermal growth factor receptor;EGFR;observational study;
Data
Language: |
English |
Year of publishing: |
2018 |
Typology: |
1.01 - Original Scientific Article |
Publisher: |
Future Medicine Ltd |
UDC: |
616-006 |
COBISS: |
2048432753
|
ISSN: |
1744-8301 |
Views: |
918 |
Downloads: |
519 |
Average score: |
0 (0 votes) |
Metadata: |
|
Other data
Secondary keywords: |
nedrobnocelični pljučni rak;afatinib;osimertinib;receptor za epidermalni rastni dejavnik;EGFR;opazovalna raziskava;Lung neoplasms;Therapy;Pljučne novotvorbe;Terapija; |
Source comment: |
Soavtorji: Alessandro Morabito, Desiree Hao, Cheng-Ta Yang, Ross A Soo, James C-H Yang, Rasim Gucalp, Balazs Halmos, Lara Wang, Amanda Golembesky, Angela Märten & Tanja Cufer;
Nasl. z nasl. zaslona;
Opis vira z dne 9. 1. 2019;
|
Pages: |
str. 2861-2874 |
Volume: |
ǂVol. ǂ14 |
Issue: |
ǂno. ǂ27 |
Chronology: |
Nov. 2018 |
DOI: |
10.2217/fon-2018-0711 |
ID: |
12143216 |