ǂan ǂobservational study
Maximilian J Hochmair (Author), Alessandro Morabito (Author), Desiree Hao (Author), Cheng-Ta Yang (Author), Ross A Soo (Author), James C-H Yang (Author), Rasim Gucalp (Author), Balazs Halmos (Author), Lara Wang (Author), Amanda Golembesky (Author), Angela Märten (Author), Tanja Čufer (Author)

Abstract

Aim: To assess outcomes in patients with EGFR mutation-positive (Del19, L858R) non-small-cell lung cancer receiving sequential afatinib and osimertinib in a real-world clinical setting. Materials & methods: In this retrospective, observational, multicenter study, patients (n = 204) had T790M-positive disease following first-line afatinib and started osimertinib treatment [>/=]10 months prior to data entry. Primary outcome was time on treatment. Results: Overall median time on treatment was 27.6 months (90% CI: 25.9-31.3), 30.3 months (90% CI: 27.6-44.5) in Del19-positive patients and 46.7 months (90% CI: 26.8-not reached) in Asians. The 2-year overall survival was 78.9%. Conclusion: In real-world clinical practice, sequential afatinib and osimertinib facilitates prolonged, chemotherapy-free treatment in patients with T790M acquired resistance, and is a potentially attractive strategy, especially for Del19-positive tumors.

Keywords

non-small-cell lung cancer;afatinib;osimertinib;epidermal growth factor receptor;EGFR;observational study;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Publisher: Future Medicine Ltd
UDC: 616-006
COBISS: 2048432753 Link will open in a new window
ISSN: 1744-8301
Views: 918
Downloads: 519
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Other data

Secondary keywords: nedrobnocelični pljučni rak;afatinib;osimertinib;receptor za epidermalni rastni dejavnik;EGFR;opazovalna raziskava;Lung neoplasms;Therapy;Pljučne novotvorbe;Terapija;
Source comment: Soavtorji: Alessandro Morabito, Desiree Hao, Cheng-Ta Yang, Ross A Soo, James C-H Yang, Rasim Gucalp, Balazs Halmos, Lara Wang, Amanda Golembesky, Angela Märten & Tanja Cufer; Nasl. z nasl. zaslona; Opis vira z dne 9. 1. 2019;
Pages: str. 2861-2874
Volume: ǂVol. ǂ14
Issue: ǂno. ǂ27
Chronology: Nov. 2018
DOI: 10.2217/fon-2018-0711
ID: 12143216