Tilen Kopač (Author), Matjaž Krajnc (Author), Aleš Ručigaj (Author)

Abstract

Ionically crosslinked hydrogels based on TEMPO nanocelullose and alginate were prepared to develop a generalized pH value, temperature and biopolymer concentration dependent mathematical model. The distinctive attention was in the demonstration of hydrogen bonds effects in the mathematical model, prevailing especially in the field of low crosslink densities of TEMPO nanocellulose hydrogel in acid medium. Accordingly, alginate hydrogelswere subjected to the research as comparable samples with less significant hydrogel bonds effect. The equation was built upon the determination of the average mesh size in a TEMPO nanocellulose and alginate hydrogel network and studying its changes in different pH release environments. Based on rheological measurements of TEMPO nanocellulose and alginate from the basic and acidic release environment, the mechanism of swelling and shrinkage was thoroughly discussed as well as the influence of substituent groups, ionic interactions and hydrogen bonds in different pH medium were evaluated. Due to the protonation of carboxylic groups, TEMPO nanocellulose and alginate hydrogels shrink in an acid environment. The presented approach will accelerate, improve and reduce the cost of research in the field of controlled release technology with target drug delivery.

Keywords

TEMPO nanoceluloza;pH odzivni hidrogel;dostavni sistem učinkovin;kontrolirano sproščanje;TEMPO nanocellulose;pH sensitive hydrogel;controlled drug delivery system;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
UDC: 661.728:620.3
COBISS: 40059651 Link will open in a new window
ISSN: 0141-8130
Views: 521
Downloads: 264
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: TEMPO nanoceluloza;pH odzivni hidrogel;dostavni sistem učinkovin;kontrolirano sproščanje;
Type (COBISS): Article
Pages: str. 695-707
Issue: ǂVol. ǂ168
Chronology: 31 Jan. 2021
DOI: 10.1016/j.ijbiomac.2020.11.126
ID: 12212339