Tilen Kopač (Avtor), Ana Lisac (Avtor), Rok Mravljak (Avtor), Aleš Ručigaj (Avtor), Matjaž Krajnc (Avtor), Aleš Podgornik (Avtor)

Povzetek

The role of bacteriophage therapy in medicine has recently regained an important place. Oral phage delivery for gastrointestinal treatment, transport through the stomach, and fast release in the duodenum is one of such applications. In this work, an efficient polyHIPE/hydrogel system for targeted delivery of bacteriophages with rapid release at the target site is presented. T7 bacteriophages were encapsulated in low crosslinked anionic nanocellulose-based hydrogels, which successfully protected phages at pH < 3.9 (stomach) and completely lost the hydrogel network at a pH above 3.9 (duodenum), allowing their release. Hydrogels with entrapped phages were crosslinked within highly porous spherical polyHIPE particles with an average diameter of 24 µm. PolyHIPE scaffold protects the hydrogels from mechanical stimuli during transport, preventing the collapse of the hydrogel structure and the unwanted phage release. On the other hand, small particle size, due to the large surface-to-volume ratio, enables rapid release at the target site. As a consequence, a fast zero-order release was achieved, providing improved patient compliance and reduced frequency of drug administration. The proposed system therefore exhibits significant potential for a targeted drug delivery in medicine and pharmacy.

Ključne besede

TEMPO nanoceluloza;bakteriofag T7;inkapsulacija;difuzija učinkovin;sproščanje ničtega reda;TEMPO nanocellulose;T7 bacteriophage;encapsulation;drug diffusion;zero-order release;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK: 678:615:578.81
COBISS: 73830403 Povezava se bo odprla v novem oknu
ISSN: 2073-4360
Št. ogledov: 318
Št. prenosov: 88
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: TEMPO nanoceluloza;bakteriofag T7;inkapsulacija;difuzija učinkovin;sproščanje ničtega reda;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-12
Letnik: ǂVol. ǂ13
Zvezek: ǂiss. ǂ16
Čas izdaje: Aug. 2021
DOI: 10.3390/polym13162648
ID: 13275173