Morphologic and molecular classification of lung neuroendocrine neoplasms

Jasna Metovic (Author), Marco Barella (Author), Fabrizio Bianchi (Author), Paul Hofman (Author), Veronique Hofman (Author), Myriam Remmelink (Author), Izidor Kern (Author), Lina Carvalho (Author), Linda Pattini (Author), Angelica Sonzogni (Author)

Abstract

Neuroendocrine neoplasms (NENs) of the lung encompass neuroendocrine tumors (NETs) composed of typical (TC) and atypical (AC) carcinoids and full-fledged carcinomas (NECs) inclusive of large cell neuroendocrine carcinoma (LCNEC) and small cell carcinoma (SCLC). NETs and NECs are thought to represent distinct and separate lesions with neither molecular overlap nor common developmental continuum. Two perspectives were addressed regarding the morphologic and molecular classification of lung NENs: (i) a supervised approach by browsing the traditional classification, the relevant gene alterations, and their clinical implications; and (ii) an unsupervised approach, by reappraising neoplasms according to risk factors and natural history of disease to construct an interpretation model relied on biological data. We herein emphasize lights and shadows of the current classification of lung NENs and provide an alternative outlook on these tumors focused on what we currently know about the biological determinants and the natural history of disease.

Keywords

pljučni tumorji;morfološka klasifikacija;molekularna klasifikacija;lung tumors;morphologic classification;molecular classification;

Data

Language:	English
Year of publishing:	2021
Typology:	1.02 - Review Article
Publisher:	Springer Nature
UDC:	616-006
COBISS:	49608195
ISSN:	1432-2307
Views:	743
Downloads:	382
Average score:	0 (0 votes)
Metadata:

Other data

Secondary keywords:	Neuroendocrine tumors;Lung neoplasms;Carcinoma;Nevroendokrini tumorji;Pljučne novotvorbe;Karcinom;
Source comment:	Nasl. z nasl. zaslona; Soavtor iz Slovenije: Izidor Kern; Opis vira z dne 1. 2. 2021;
Pages:	str. 5-19
Volume:	ǂVol. ǂ478
Issue:	ǂiss. ǂ1
Chronology:	Jan. 2021
DOI:	10.1007/s00428-020-03015-z
ID:	12525333