Jošt Stergar (Author), Rok Dolenec (Author), Nika Kojc (Author), Katja Lakota (Author), Martina Perše (Author), Matija Tomšič (Author), Matija Milanič (Author)

Abstract

Analysis of morphological changes of the peritoneal membrane is an essential part of animal studies when investigating molecular mechanisms involved in the development of peritoneal fibrosis or testing the effects of potential therapeutic agents. Current methods, such as histology and immunohistochemistry, require time consuming sample processing and analysis and result in limited spatial information. In this paper we present a new method to evaluate structural and chemical changes in an animal model of peritoneal fibrosis that is based on hyperspectral imaging and a model of light transport. The method is able to distinguish between healthy and diseased subjects based on morphological as well as physiological parameters such as blood and scattering parameters. Furthermore, it enables evaluation of changes, such as degree of inflammation and fibrosis, that are closely related to histological findings.

Keywords

medicinska fizika;medicinsko slikanje;medical physics;medical imaging;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FMF - Faculty of Mathematics and Physics
UDC: 616-073
COBISS: 3414372 Link will open in a new window
ISSN: 2156-7085
Views: 452
Downloads: 120
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: medicinska fizika;medicinsko slikanje;
Type (COBISS): Article
Pages: str. 1991-2006
Volume: ǂVol. ǂ11
Issue: ǂno. ǂ4
Chronology: 2020
DOI: 10.1364/BOE.387837
ID: 13157074