Jošt Stergar (Avtor), Rok Dolenec (Avtor), Nika Kojc (Avtor), Katja Lakota (Avtor), Martina Perše (Avtor), Matija Tomšič (Avtor), Matija Milanič (Avtor)

Povzetek

Analysis of morphological changes of the peritoneal membrane is an essential part of animal studies when investigating molecular mechanisms involved in the development of peritoneal fibrosis or testing the effects of potential therapeutic agents. Current methods, such as histology and immunohistochemistry, require time consuming sample processing and analysis and result in limited spatial information. In this paper we present a new method to evaluate structural and chemical changes in an animal model of peritoneal fibrosis that is based on hyperspectral imaging and a model of light transport. The method is able to distinguish between healthy and diseased subjects based on morphological as well as physiological parameters such as blood and scattering parameters. Furthermore, it enables evaluation of changes, such as degree of inflammation and fibrosis, that are closely related to histological findings.

Ključne besede

medicinska fizika;medicinsko slikanje;medical physics;medical imaging;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FMF - Fakulteta za matematiko in fiziko
UDK: 616-073
COBISS: 3414372 Povezava se bo odprla v novem oknu
ISSN: 2156-7085
Št. ogledov: 452
Št. prenosov: 120
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: medicinska fizika;medicinsko slikanje;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1991-2006
Letnik: ǂVol. ǂ11
Zvezek: ǂno. ǂ4
Čas izdaje: 2020
DOI: 10.1364/BOE.387837
ID: 13157074