Okoljsko prijazna in napredna funkcionalizacija silikona za razvoj novih medicinskih pripomočkov

magistrsko delo

Katja Kuzmič (Author), Tamilselvan Mohan (Mentor), Lidija Fras Zemljič (Co-mentor), Matej Bračič (Co-mentor)

Abstract

Prekomerna uporaba antibiotikov za zdravljenje infekcij vodi v naraščanje števila odpornih bakterij, kar predstavlja grožnjo javnemu zdravju. Strategije zmanjševanja uporabe temeljijo tudi na preprečevanju nastanka bakterijskega biofilma na površinah medicinskih pripomočkov. Predstavljamo metodo funkcionalizacije silikona z oplaščenjem z naravnimi bioaktivnimi substancami. Na silikon smo kot vezni polimer adsorbirali biopolimer polidopamin, na katerega smo kovalentno vezali karbokismetil hitozan s tiolnimi funkcionalnimi skupinami, ki izkazuje protimikrobne in biofilm-inhibitorne lastnosti. Rezultati karakterizacije so pokazali uspešno kovalentno vezavo karboksimetil hitozana preko tiolnih skupin na polidopamin, kar je pripomoglo k zmanjšanju tvorbe biofilma na površini v primerjavi s fizikalno vezanim karboksimetil hitozanom in neobdelanim silikonom.

Keywords

biopolimeri;biofunkcionalizacija;protimikrobnost;polidopamin;karboksimetil hitozan;magistrske naloge;

Data

Language:	Slovenian
Year of publishing:	2021
Typology:	2.09 - Master's Thesis
Organization:	UM FS - Faculty of Mechanical Engineering
Publisher:	[K. Kuzmič]
UDC:	577.11:615.8-7(043.2)
COBISS:	82421251
Views:	338
Downloads:	41
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Environmentally friendly and advanced functionalization of silicone for the development of new medical devices
Secondary abstract:	Excessive use of antibiotics to treat infections leads to an increase in the number of resistant bacteria, which poses a threat to public health. Strategies to reduce the use of antibiotics are also based on preventing the formation of bacterial biofilm on the surfaces of medical devices. In this work, we present a method of functionalizing silicone by coating it with natural bioactive substances. The biopolymer polydopamine was adsorbed on the silicon as a binding polymer, to which carboxymethyl chitosan was covalently bound with thiol functional groups exhibiting antimicrobial and biofilm-inhibitory properties. The characterization results showed successful covalent binding of carboxymethyl chitosan via thiol groups to polydopamine, which helped to reduce surface biofilm formation compared to physically bound carboxymethyl chitosan and untreated silicone.
Secondary keywords:	biopolymers;biofunctionalization;antimicrobial;polydopamine;carboxymethyl chitosan;
Type (COBISS):	Master's thesis/paper
Thesis comment:	Univ. v Mariboru, Fak. za strojništvo, Tehniško varstvo okolja
Pages:	VIII, 71 str.
ID:	13272743