Maruša Novak (Author), Kristina Sepčić (Author), Nada Kraševec (Author), Igor Križaj (Author), Peter Maček (Author), Gregor Anderluh (Author), Graziano Guella (Author), Ines Mancini (Author)

Abstract

Ethanolic extracts of mycelia from Aspergillus niger (strain N402) grown in liquid media were observed to have haemolytic activity on bovine erythrocytes. This haemolytic activity decreased significantly during the time of growth (1–3 days). Moreover, when A. niger was grown on carbon-deprived medium, the efficiency of this haemolytic activity in the ethanolic extracts was much lower than when grown in carbon-enriched medium, and became almost undetectable after 3 days of growth in carbon-deprived medium. The lipid composition of these ethanolic extracts was analysed by liquid chromatography–electrospray ionisation tandem mass spectrometry. This haemolytic activity can be mainly linked to the relative levels of the molar ratios of the unsaturated fatty acids and lysophosphatidylcholines.

Keywords

haemolytic activity;fatty acids;lipid composition;liquid chromatography-selectrospray ionisation tandem mass spectrometry;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL BF - Biotechnical Faculty
UDC: 577.1
COBISS: 3158095 Link will open in a new window
ISSN: 1420-3049
Views: 280
Downloads: 56
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Other data

Type (COBISS): Article
Pages: str. 9051-9069
Volume: ǂVol. ǂ19
Issue: ǂno. ǂ7
Chronology: 2014
DOI: 10.3390/molecules19079051
ID: 13296248