Bojana Črček (Author), Jernej Baškovč (Author), Uroš Grošelj (Author), Drago Kočar (Author), Georg Dahmann (Author), Branko Stanovnik (Author), Jurij Svete (Author)

Abstract

A library of 24 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxamides 10{1,2; 1–12} was prepared by a parallel solution-phase approach. The synthesis comprises a five-step transformation of itaconic acid (11) into 1-methyl and 1-phenyl substituted 6-(5-oxo-1-phenylpyrrolidin-3-yl)pyrimidine-5-carboxylic acids 17{1,2} followed by parallel amidation of 17{1,2} with a series of 12 aliphatic amines 18{1–12} to afford the corresponding carboxamides 10 in good overall yields and in 80–100% purity.

Keywords

organska kemija;sinteze;paralelna sinteza;organske reakcije;struktura spojin;NMR spektri;heterociklične spojine;heterociklični sistemi;heterocikli;derivati pirimidina;pirimidini;derivati amina;2-(heteroaril)etilamini;karboksamidi;parallel synthesis;pyrimidines;2-(heteroaryl)ethylamines;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
UDC: 547.853.022.057
COBISS: 35944709 Link will open in a new window
ISSN: 1420-3049
Views: 260
Downloads: 49
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: organska kemija;sinteze;paralelna sinteza;organske reakcije;struktura spojin;NMR spektri;heterociklične spojine;heterociklični sistemi;heterocikli;derivati pirimidina;pirimidini;derivati amina;2-(heteroaril)etilamini;karboksamidi;
Type (COBISS): Article
Pages: str. 5363-5384
Volume: ǂVol. ǂ17
Issue: ǂno. ǂ5
Chronology: 2012
DOI: 10.3390/molecules17055363
ID: 13310987