Pouline M. van Oort (Author), Tamara M. E. Nijsen (Author), I. R. White (Author), Hugo Knobel (Author), Timothy Felton (Author), Nicholas J. W. Rattray (Author), Oluwasola Lawal (Author), Murtaza Bulut (Author), Waqar Ahmed (Author), Antonio Artigas (Author)

Abstract

Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA-LRTI with confirmed infection, from patients with negative cultures. Breath from 108 patients suspected of VA-LRTI was analysed by gas chromatography-mass spectrometry. The breath test had a sensitivity of 98% at a specificity of 49%, confirmed with a second analytical method. The breath test had a negative predictive value of 96% and excluded pneumonia in half of the patients with negative cultures. Trial registration number: UKCRN ID number 19086, registered May 2015.

Keywords

ventilator-associated pneumonia;breath analysis;volatile organic compounds;metabolomics;intensive care;hospital acquired infections;

Data

Language: English
Year of publishing:
Typology: 1.03 - Short Scientific Article
Organization: UNG - University of Nova Gorica
UDC: 616.2
COBISS: 75487235 Link will open in a new window
ISSN: 0040-6376
Views: 1354
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Other data

URN: URN:SI:UNG
Pages: str. 1-3
Volume: ǂVol. ǂ
Issue: ǂiss. ǂ
Chronology: 2021
DOI: 10.1136/thoraxjnl-2021-217362
ID: 13324803
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