Optimizacija procesa ekstrakcije farmacevtske učinkovine

magistrsko delo

Matej Furek (Author), Miloš Bogataj (Mentor), Zorka Novak-Pintarič (Co-mentor), Peter Pečelin (Co-mentor)

Abstract

V magistrskem delu predstavljamo ekstrakcijo aktivne farmacevtske učinkovine iz vodne v organsko fazo z uporabo ekstrakcijsko-separacijskih centrifug. Izvedli smo simulacijo proizvodnega procesa ekstrakcije, ki je sestavljen iz šestih ekstrakcijsko-separacijskih centrifug (Westfalia). Simulacijo smo izvedli na osnovi podatkov, ki smo jih pridobili iz proizvodnje. Simulirali smo trenutno postavitev centrifug (1-1-1-1-1) ter izvedli simulacije štirih alternativnih postavitev centrifug. Rezultati nakazujejo, da se rezultati simulacije osnovne postavitve skladajo s podatki realnega procesa, na podlagi česar sklepamo, da so skladni tudi rezultati alternativnih postavitev. Na osnovi eksperimentalnega načrta smo razvili matematične modele za napovedovanje izkoristkov obravnavanih postavitev ekstrakcijsko-separacijskih centrifug. Polinomski matematični modeli za oceno učinkovitosti posamezne postavitve izkazujejo visoko ujemanje s podatki (R2 > 0,98). Razvite modele smo uporabili za optimizacijo procesa ekstrakcije. Rezultati optimizacije nakazujejo, da bi lahko z alternativno postavitvijo (2-1-1-1) dosegli enako učinkovitost, kar bi sicer zahtevalo 750 L/h višji pretok organskega topila, vendar bi s tem močno razbremenili centrifugi v prvi stopnji.

Keywords

ekstrakcijsko-separacijske centrifuge;aktivna farmacevtska učinkovina;simulacija;optimizacija;magistrske naloge;

Data

Language:	Slovenian
Year of publishing:	2021
Typology:	2.09 - Master's Thesis
Organization:	UM FKKT - Faculty of Chemistry and Chemical Engineering
Publisher:	[M. Furek]
UDC:	66.061.3.011(043.2)
COBISS:	77466627
Views:	326
Downloads:	41
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Optimization of the pharmaceutical compound extraction process
Secondary abstract:	In the master thesis we present the extraction of active pharmaceutical ingredients from aqueous to organic phase using extraction-separation centrifuges. We have performed a simulation of the industrial extraction process, which comprises six extraction-separation centrifuges (Westfalia). The simulation was performed using Aspen Plus based on data from the production process. We simulated the currently installed centrifuge layout (1-1-1-1-1) and performed simulations of four alternative layouts. The results show that the simulation results of the current process layout are consistent with the results of the industrial installation. Therefore, we can conclude that the results of the alternative layouts are also consistent. We have developed mathematical models for predicting the extraction efficiency of the studied centrifuge layouts. The polynomial mathematical models for evaluating the efficiency of the individual layout exhibit high goodness-of-fit (R2 0.98). The models were used to optimize the extraction process. The optimization results indicate that the alternative centrifuge layout (2-1-1-1) centrifuge could be as efficient as the current one. This layout would require 750 L/h higher flow rate of organic solvent; however, the load on the centrifuges in the first stage would be greatly reduced.
Secondary keywords:	extraction-separation centrifuge;active pharmaceutical ingredient;simulation;optimization;
Type (COBISS):	Master's thesis/paper
Thesis comment:	Univ. v Mariboru, Fak. za kemijo in kemijsko tehnologijo
Pages:	VII, 48 str.
ID:	13332783