diplomsko delo
Ana Cizerl (Author), Jakob Kljun (Mentor)

Abstract

V sklopu svoje diplomske naloge sem optimizirala sintezni poti nastanka 1,2,4-triazolidin-3-tionov in 1,3,4-tiadiazolov. Pri tem sem uspela sintetizirati sedem različnih 1,2,4-triazolidin-3-tionov in tri 1,3,4-tiadiazole. Te spojine so znane po širokem spektru farmacevtskih lastnosti. Izkoristki sintez sicer niso najboljši, ampak to bi verjetno lahko izboljšala z nadaljnjo optimizacijo sinteznih postopkov. Dobljene spojine sem okarakterizirala z NMR, HRMS, elementno analizo; v dveh primerih sem imela primerne kristale za rentgensko strukturno analizo. Namen naloge je bil tudi preučiti način vezave ligandov na modelne cinkove spojine. S pomočjo teh modelnih spojin bi se preučeval način in jakost vezave sintetiziranih molekul v aktivna mesta metaloencimov. Pregledala sem znanstveno literaturo in povzela, kako bi te modelne cinkove spojine lahko sintetizirala.

Keywords

farmacevtska kemija;metaloproteini;metaloencimi;cinkovi modelni kompleksi;triazolidin-3-tioni;tiadiazoli;sinteza;diplomska dela;

Data

Language: Slovenian
Year of publishing:
Typology: 2.11 - Undergraduate Thesis
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher: [A. Cizerl]
UDC: 547.78:546.47(043.2)
COBISS: 83215107 Link will open in a new window
Views: 250
Downloads: 44
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Other data

Secondary language: English
Secondary title: Synthesis of heterocyclic compounds from thiosemicarbazides and study of their binding to zinc model compounds of metalloprotein active sites
Secondary abstract: As part of my thesis, I optimized the synthetic pathways of 1,2,4-triazolidin-3-thiones and 1,3,4-thiadiazoles. In doing so, I was able to synthesize seven different 1,2,4-triazolidin-3-thiones and three 1,3,4-thiadiazoles. These compounds are known for a wide range of pharmaceutical properties. Although the synthesis yields are not the best, this could probably be improved by further optimizing the synthesis processes. The obtained compounds were characterized by NMR, HRMS and elemental analysis. For two compounds suitable crystals for X-ray structural analysis were obtained. The purpose of the task was to study the method of binding ligands to model zinc compounds. Utilizing these model compounds, the mode and strength of binding of synthesized molecules to active sites of metalloenzymes would be studied. I reviewed the scientific literature and summarized how these compounds could be synthesized.
Secondary keywords: synthesis;triazolidin-3-thiones;thiadiazoles;zinc model complexes;
Type (COBISS): Bachelor thesis/paper
Study programme: 1000373
Embargo end date (OpenAIRE): 1970-01-01
Thesis comment: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Pages: 44 str.
ID: 13381018