diplomsko delo
Ana Cizerl (Avtor), Jakob Kljun (Mentor)

Povzetek

V sklopu svoje diplomske naloge sem optimizirala sintezni poti nastanka 1,2,4-triazolidin-3-tionov in 1,3,4-tiadiazolov. Pri tem sem uspela sintetizirati sedem različnih 1,2,4-triazolidin-3-tionov in tri 1,3,4-tiadiazole. Te spojine so znane po širokem spektru farmacevtskih lastnosti. Izkoristki sintez sicer niso najboljši, ampak to bi verjetno lahko izboljšala z nadaljnjo optimizacijo sinteznih postopkov. Dobljene spojine sem okarakterizirala z NMR, HRMS, elementno analizo; v dveh primerih sem imela primerne kristale za rentgensko strukturno analizo. Namen naloge je bil tudi preučiti način vezave ligandov na modelne cinkove spojine. S pomočjo teh modelnih spojin bi se preučeval način in jakost vezave sintetiziranih molekul v aktivna mesta metaloencimov. Pregledala sem znanstveno literaturo in povzela, kako bi te modelne cinkove spojine lahko sintetizirala.

Ključne besede

farmacevtska kemija;metaloproteini;metaloencimi;cinkovi modelni kompleksi;triazolidin-3-tioni;tiadiazoli;sinteza;diplomska dela;

Podatki

Jezik: Slovenski jezik
Leto izida:
Tipologija: 2.11 - Diplomsko delo
Organizacija: UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
Založnik: [A. Cizerl]
UDK: 547.78:546.47(043.2)
COBISS: 83215107 Povezava se bo odprla v novem oknu
Št. ogledov: 250
Št. prenosov: 44
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Angleški jezik
Sekundarni naslov: Synthesis of heterocyclic compounds from thiosemicarbazides and study of their binding to zinc model compounds of metalloprotein active sites
Sekundarni povzetek: As part of my thesis, I optimized the synthetic pathways of 1,2,4-triazolidin-3-thiones and 1,3,4-thiadiazoles. In doing so, I was able to synthesize seven different 1,2,4-triazolidin-3-thiones and three 1,3,4-thiadiazoles. These compounds are known for a wide range of pharmaceutical properties. Although the synthesis yields are not the best, this could probably be improved by further optimizing the synthesis processes. The obtained compounds were characterized by NMR, HRMS and elemental analysis. For two compounds suitable crystals for X-ray structural analysis were obtained. The purpose of the task was to study the method of binding ligands to model zinc compounds. Utilizing these model compounds, the mode and strength of binding of synthesized molecules to active sites of metalloenzymes would be studied. I reviewed the scientific literature and summarized how these compounds could be synthesized.
Sekundarne ključne besede: synthesis;triazolidin-3-thiones;thiadiazoles;zinc model complexes;
Vrsta dela (COBISS): Diplomsko delo/naloga
Študijski program: 1000373
Konec prepovedi (OpenAIRE): 1970-01-01
Komentar na gradivo: Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, UNI Kemija
Strani: 44 str.
ID: 13381018