Irina Milisav (Author), Dušan Šuput (Author), Samo Ribarič (Author)

Abstract

Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions.

Keywords

Alzheimer's disease;;autophagy;Parkinson's disease;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616-092
COBISS: 32400601 Link will open in a new window
ISSN: 1420-3049
Views: 0
Downloads: 0
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Unknown
Secondary keywords: Alzheimerjeva bolezen;avtofagija;Parkinsonova bolezen;
Type (COBISS): Not categorized
Pages: str. 22718-22756
Volume: ǂVol. ǂ20
Issue: ǂno. ǂ12
Chronology: Oct. 2015
DOI: 10.3390/molecules201219865
ID: 13403691