Irina Milisav (Avtor), Dušan Šuput (Avtor), Samo Ribarič (Avtor)

Povzetek

Proteostasis are integrated biological pathways within cells that control synthesis, folding, trafficking and degradation of proteins. The absence of cell division makes brain proteostasis susceptible to age-related changes and neurodegeneration. Two key processes involved in sustaining normal brain proteostasis are the unfolded protein response and autophagy. Alzheimer's disease (AD), Parkinson's disease (PD) and prion diseases (PrDs) have different clinical manifestations of neurodegeneration, however, all share an accumulation of misfolded pathological proteins associated with perturbations in unfolded protein response and macroautophagy. While both the unfolded protein response and macroautophagy play an important role in the prevention and attenuation of AD and PD progression, only macroautophagy seems to play an important role in the development of PrDs. Macroautophagy and unfolded protein response can be modulated by pharmacological interventions. However, further research is necessary to better understand the regulatory pathways of both processes in health and neurodegeneration to be able to develop new therapeutic interventions.

Ključne besede

Alzheimer's disease;;autophagy;Parkinson's disease;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616-092
COBISS: 32400601 Povezava se bo odprla v novem oknu
ISSN: 1420-3049
Št. ogledov: 0
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Neznan jezik
Sekundarne ključne besede: Alzheimerjeva bolezen;avtofagija;Parkinsonova bolezen;
Vrsta dela (COBISS): Delo ni kategorizirano
Strani: str. 22718-22756
Letnik: ǂVol. ǂ20
Zvezek: ǂno. ǂ12
Čas izdaje: Oct. 2015
DOI: 10.3390/molecules201219865
ID: 13403691