Razvoj kontinuirnega procesa sinteze farmacevtskega intermediata v mikropretočnem sistemu

magistrsko delo

Jan Zupančič (Author), Polona Žnidaršič Plazl (Mentor), Marjan Marinšek (Thesis defence commission member), Igor Plazl (Thesis defence commission member)

Abstract

Številne študije nakazujejo, da mikro in mezopretočni sistemi zaradi svojih lastnosti, predvsem učinkovitega prenosa toplote in snovi, predstavljajo odlično orodje za moderno proizvodnjo finih kemikalij in farmacevtskih učinkovin. Z njimi lahko izboljšamo izkoristek in selektivnost procesa ter obenem zmanjšamo porabo energije, topil in reagentov, s pomočjo avtomatizacije pa tudi človeško delo. Zaradi naštetih lastnosti je implementacija te tehnologije pri sintezi aktivnih farmacevtskih učinkovin ena izmed glavnih smeri razvoja trajnostne proizvodnje. Magistrsko delo obravnava prenos sinteze intermediata izbrane aktivne farmacevtske učinkovine iz šaržnega v mikro in mezopretočni sistem. V ta namen smo preučili lastnosti uporabljenih surovin za sintezo in pridobili osnovne podatke o procesu s šaržnim obratovanjem. V nadaljevanju pa smo sintezo izvedli v mikroreaktorjih z različnimi tokovnimi profili, načini mešanja in doziranja reaktantov ter končno še v mezopretočnem reaktorju. Na podlagi pridobljenih rezultatov smo ugotovili, da pri reakciji nastajajo stranski produkti, ki negativno vplivajo na njen potek, v kolikor se jih ne odstrani takoj ob nastanku, da je hitrost obravnavanega procesa primarno omejena s kinetiko same reakcije in ne s prenosom toplote in snovi, ter da učinkovit prenos toplote v mikropretočnih sistemih omogoča hitrejše dodajanje reagentov, ob dodatku katerih pride do eksotermnih procesov.

Keywords

mikroreaktorji;kontinuirni proces;pretočni sistem;mikropretočna tehnologija;organska sinteza;aktivne farmacevtske učinkovine;magistrska dela;

Data

Language:	Slovenian
Year of publishing:	2021
Typology:	2.09 - Master's Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[J. Zupančič]
UDC:	66.02.098(043.2)
COBISS:	90764291
Views:	158
Downloads:	22
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Development of a continuous process for the synthesis of a pharmaceutical intermediate in a microfluidic system
Secondary abstract:	Numerous studies indicate that micro- and meso-flow systems are excellent tools for modern production of fine chemicals and active pharmaceutical ingredients due to their properties, especially efficient heat and mass transfer. By using them, we can improve the yields and selectivity of a process while reducing the consumption of energy, solvents and reagents and, with the help of automation, human labor. For the above reasons, the implementation of micro- and meso-flow technologies for the production of active pharmaceutical ingredients is one of the main routes for the transition to sustainable production. The master thesis deals with the transfer of the synthesis of the intermediate of the selected active pharmaceutical ingredient from batch to the micro- and meso-flow systems. For this purpose, the properties of the raw materials used for the synthesis were studied and basic data on the batch operation of the process were obtained. The synthesis was then carried out in microreactors with different flow patterns, mixing modes and dosages of reactants and finally also in a meso-flow reactor. Based on the results obtained, it was concluded that by-products formed during the reaction negatively affect the process and should be removed in situ. It was also found that the process is primarily limited by reaction kinetics rather than heat and mass transfer. Efficient heat transfer in microflow systems also allows faster dosing of reagents that cause exothermic reactions.
Secondary keywords:	microreactors;continuous process;active pharmaceutical ingredient;organic synthesis;flow system;
Type (COBISS):	Master's thesis/paper
Study programme:	1000376
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, smer Kemijsko inženirstvo
Pages:	65 str.
ID:	14101861