Witold Musiał (Author), Vanja Kokol (Author), Bojana Vončina (Author)

Abstract

The aim of present work was preliminary assessment of the conductivity changes in aqueous compartment, consisting of lidocaine hydrochloride, and N-isopropylacrylamide derivative microgel, during increasing the temperature between 25° and 42°C, as a prerequisite to demonstrate the possibility of applying this microgel for pulsed release of lidocaine hydrochloride, when increased temperature is applied. Conductivity of respective systems composed of polymer and lidocaine hydrochloride were assigned as PNM I-LD, PNM II-LD, and PNM III - LD: obtained values were in the ranges: 39,91 muS/cm - 53,30 muS/cm in the 25°C temperature, 46,14 muS/cm - 56,16 muS/cm in the temperature of 32°C, and 53,30 muS/cm - 118,42 muS/cm at 42°C. During heating or cooling of the microgels derivatives of N-isopropylacrylamide, there is possibility to obtain pulsed release of lidocaine hydrochloride from the polymeric bead in the range between 25°C and 42°C, according to the conductivity measurements.

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Data

Language: Polish
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FS - Faculty of Mechanical Engineering
UDC: 677.017:543
COBISS: 14721302 Link will open in a new window
ISSN: 0370-0747
Views: 1108
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Secondary language: English
Secondary title: ǂThe ǂuse of conductometric assessments for development of pulsed release of lidocaine hydrochloride from thermosensitive N-isopropylacrylamide microgels
Secondary abstract: The aim of present work was preliminary assessment of the conductivity changes in aqueous compartment, consisting of lidocaine hydrochloride, and N-isopropylacrylamide derivative microgel, during increasing the temperature between 25° and 42°C, as a prerequisite to demonstrate the possibility of applying this microgel for pulsed release of lidocaine hydrochloride, when increased temperature is applied. Conductivity of respective systems composed of polymer and lidocaine hydrochloride were assigned as PNM I-LD, PNM II-LD, and PNM III - LD: obtained values were in the ranges: 39,91 muS/cm - 53,30 muS/cm in the 25°C temperature, 46,14 muS/cm - 56,16 muS/cm in the temperature of 32°C, and 53,30 muS/cm - 118,42 muS/cm at 42°C. During heating or cooling of the microgels derivatives of N-isopropylacrylamide, there is possibility to obtain pulsed release of lidocaine hydrochloride from the polymeric bead in the range between 25°C and 42°C, according to the conductivity measurements.
Secondary keywords: lidocaine hydrochloride;microgels;N-isopropylacrylamide;pulsed release;thermosensitivity;conductivity;
URN: URN:SI:UM:
Pages: [30] str.
Volume: ǂT. ǂ39
Issue: ǂno. ǂ4
Chronology: 2009
Keywords (UDC): applied sciences;medicine;technology;uporabne znanosti;medicina;tehnika;various industries;trades and crafts;razne industrije;obrti in rokodelstva;textile industry;tekstilna industrija;mathematics;natural sciences;naravoslovne vede;matematika;chemistry;crystallography;mineralogy;kemija;analytical chemistry;analizna kemija;
ID: 1438854