Witold Musiał (Avtor), Vanja Kokol (Avtor), Bojana Vončina (Avtor)

Povzetek

The aim of present work was preliminary assessment of the conductivity changes in aqueous compartment, consisting of lidocaine hydrochloride, and N-isopropylacrylamide derivative microgel, during increasing the temperature between 25° and 42°C, as a prerequisite to demonstrate the possibility of applying this microgel for pulsed release of lidocaine hydrochloride, when increased temperature is applied. Conductivity of respective systems composed of polymer and lidocaine hydrochloride were assigned as PNM I-LD, PNM II-LD, and PNM III - LD: obtained values were in the ranges: 39,91 muS/cm - 53,30 muS/cm in the 25°C temperature, 46,14 muS/cm - 56,16 muS/cm in the temperature of 32°C, and 53,30 muS/cm - 118,42 muS/cm at 42°C. During heating or cooling of the microgels derivatives of N-isopropylacrylamide, there is possibility to obtain pulsed release of lidocaine hydrochloride from the polymeric bead in the range between 25°C and 42°C, according to the conductivity measurements.

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Podatki

Jezik: Polski jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UM FS - Fakulteta za strojništvo
UDK: 677.017:543
COBISS: 14721302 Povezava se bo odprla v novem oknu
ISSN: 0370-0747
Št. ogledov: 1108
Št. prenosov: 10
Ocena: 0 (0 glasov)
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Ostali podatki

Sekundarni jezik: Angleški jezik
Sekundarni naslov: ǂThe ǂuse of conductometric assessments for development of pulsed release of lidocaine hydrochloride from thermosensitive N-isopropylacrylamide microgels
Sekundarni povzetek: The aim of present work was preliminary assessment of the conductivity changes in aqueous compartment, consisting of lidocaine hydrochloride, and N-isopropylacrylamide derivative microgel, during increasing the temperature between 25° and 42°C, as a prerequisite to demonstrate the possibility of applying this microgel for pulsed release of lidocaine hydrochloride, when increased temperature is applied. Conductivity of respective systems composed of polymer and lidocaine hydrochloride were assigned as PNM I-LD, PNM II-LD, and PNM III - LD: obtained values were in the ranges: 39,91 muS/cm - 53,30 muS/cm in the 25°C temperature, 46,14 muS/cm - 56,16 muS/cm in the temperature of 32°C, and 53,30 muS/cm - 118,42 muS/cm at 42°C. During heating or cooling of the microgels derivatives of N-isopropylacrylamide, there is possibility to obtain pulsed release of lidocaine hydrochloride from the polymeric bead in the range between 25°C and 42°C, according to the conductivity measurements.
Sekundarne ključne besede: lidocaine hydrochloride;microgels;N-isopropylacrylamide;pulsed release;thermosensitivity;conductivity;
URN: URN:SI:UM:
Strani: [30] str.
Letnik: ǂT. ǂ39
Zvezek: ǂno. ǂ4
Čas izdaje: 2009
Ključne besede (UDK): applied sciences;medicine;technology;uporabne znanosti;medicina;tehnika;various industries;trades and crafts;razne industrije;obrti in rokodelstva;textile industry;tekstilna industrija;mathematics;natural sciences;naravoslovne vede;matematika;chemistry;crystallography;mineralogy;kemija;analytical chemistry;analizna kemija;
ID: 1438854