Matea Nikolac Perkovic (Author), Alja Videtič (Author), Marcela Konjevod (Author), Katarina Kouter (Author), Dubravka Svob Strac (Author), Gordana Nedic Erjavec (Author), Nela Pivac (Author)

Abstract

There are currently no validated biomarkers which can be used to accurately diagnose Alzheimer's disease (AD) or to distinguish it from other dementia-causing neuropathologies. Moreover, to date, only symptomatic treatments exist for this progressive neurodegenerative disorder. In the search for new, more reliable biomarkers and potential therapeutic options, epigenetic modifications have emerged as important players in the pathogenesis of AD. The aim of the article was to provide a brief overview of the current knowledge regarding the role of epigenetics (including mitoepigenetics) in AD, and the possibility of applying these advances for future AD therapy. Extensive research has suggested an important role of DNA methylation and hydroxymethylation, histone posttranslational modifications, and non-coding RNA regulation (with the emphasis on microRNAs) in the course and development of AD. Recent studies also indicated mitochondrial DNA (mtDNA) as an interesting biomarker of AD, since dysfunctions in the mitochondria and lower mtDNA copy number have been associated with AD pathophysiology. The current evidence suggests that epigenetic changes can be successfully detected, not only in the central nervous system, but also in the cerebrospinal fluid and on the periphery, contributing further to their potential as both biomarkers and therapeutic targets in AD.

Keywords

Alzheimerjeva bolezen;epigenetika;metilacija DNA;Alzheimer's disease;epigenetics;DNA methylation;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616.8
COBISS: 49661699 Link will open in a new window
ISSN: 2218-273X
Views: 173
Downloads: 55
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Other data

Secondary language: Slovenian
Secondary keywords: Alzheimerjeva bolezen;epigenetika;metilacija DNA;
Type (COBISS): Article
Pages: str. 1-38
Volume: ǂVol. ǂ11
Issue: ǂno. ǂ2
Chronology: 2021
DOI: 10.3390/biom11020195
ID: 14495781