Luke J. Hearne (Author), Ravi D. Mill (Author), Brian P. Keane (Author), Grega Repovš (Author), Alan Anticevic (Author), Michael W. Cole (Author)

Abstract

Cognitive dysfunction is a core feature of many brain disorders such as schizophrenia (SZ), and has been linked to both aberrant brain functional connectivity (FC) and aberrant cognitive brain activations. We propose that aberrant network activity flow over FC pathways leads to altered cognitive activations that produce cognitive dysfunction in SZ. We tested this hypothesis using activity flow mapping - an approach that models the movement of task-related activity between brain regions as a function of FC. Using fMRI data from SZ individuals and healthy controls during a working memory task, we found that activity flow models accurately predict aberrant cognitive activations across multiple brain networks. Within the same framework, we simulated a connectivity-based clinical intervention, predicting specific treatments that normalized brain activations and behavior in independent patients. Our results suggest that dysfunctional task-evoked activity flow is a large-scale network mechanism contributing to the emergence of cognitive dysfunction in SZ.

Keywords

shizofrenija;možgani;nevroznanost;kognitivni upad;funkcijska konektivnost;nevronske mreže;funkcijsko magnetnoresonančno slikanje fMRI;delovni spomin;schizophrenia;brain;neurosciences;cognitive impairment;functional connectivity;neural networks;functional magnetic resonance imaging fMRI;working memory;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FF - Faculty of Arts
UDC: 159.91:616.895.8
COBISS: 48459779 Link will open in a new window
ISSN: 2375-2548
Views: 138
Downloads: 56
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Other data

Secondary language: Slovenian
Secondary keywords: tok aktivnosti;shizofrenija;možgani;nevroznanost;kognitivni upad;kognitivna motnja;funkcijska konektivnost;nevronske mreže;možganska omrežja;funkcijsko magnetnoresonančno slikanje fMRI;delovni spomin;
Pages: str. 1-13
Volume: ǂVol. ǂ7
Issue: ǂiss. ǂ29
Chronology: 2021
DOI: 10.1126/sciadv.abf2513
ID: 14545330