Luke J. Hearne (Avtor), Ravi D. Mill (Avtor), Brian P. Keane (Avtor), Grega Repovš (Avtor), Alan Anticevic (Avtor), Michael W. Cole (Avtor)

Povzetek

Cognitive dysfunction is a core feature of many brain disorders such as schizophrenia (SZ), and has been linked to both aberrant brain functional connectivity (FC) and aberrant cognitive brain activations. We propose that aberrant network activity flow over FC pathways leads to altered cognitive activations that produce cognitive dysfunction in SZ. We tested this hypothesis using activity flow mapping - an approach that models the movement of task-related activity between brain regions as a function of FC. Using fMRI data from SZ individuals and healthy controls during a working memory task, we found that activity flow models accurately predict aberrant cognitive activations across multiple brain networks. Within the same framework, we simulated a connectivity-based clinical intervention, predicting specific treatments that normalized brain activations and behavior in independent patients. Our results suggest that dysfunctional task-evoked activity flow is a large-scale network mechanism contributing to the emergence of cognitive dysfunction in SZ.

Ključne besede

shizofrenija;možgani;nevroznanost;kognitivni upad;funkcijska konektivnost;nevronske mreže;funkcijsko magnetnoresonančno slikanje fMRI;delovni spomin;schizophrenia;brain;neurosciences;cognitive impairment;functional connectivity;neural networks;functional magnetic resonance imaging fMRI;working memory;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FF - Filozofska fakulteta
UDK: 159.91:616.895.8
COBISS: 48459779 Povezava se bo odprla v novem oknu
ISSN: 2375-2548
Št. ogledov: 138
Št. prenosov: 56
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: tok aktivnosti;shizofrenija;možgani;nevroznanost;kognitivni upad;kognitivna motnja;funkcijska konektivnost;nevronske mreže;možganska omrežja;funkcijsko magnetnoresonančno slikanje fMRI;delovni spomin;
Strani: str. 1-13
Letnik: ǂVol. ǂ7
Zvezek: ǂiss. ǂ29
Čas izdaje: 2021
DOI: 10.1126/sciadv.abf2513
ID: 14545330