Supplementation with >Your< Iron Syrup corrects iron status in a mouse model of diet-induced iron deficiency

Tatjana Pirman (Author), Ajda Lenardič (Author), Alenka Nemec Svete (Author), Simon Horvat (Author)

Abstract

The objective of this study was to compare the effects of >Your< Iron Syrup, a novel oral liquid iron-containing food supplement, with the commonly prescribed iron sulphate (Fe-sulphate) in a mouse model of diet-induced iron deficiency. Standard inbred BALB/cOlaHsd mice were fed low-iron diet for 11 weeks to induce significant decrease in blood haemoglobin and haematocrit and were then supplemented by gavage with either >Your< Iron Syrup or Fe-sulphate for two weeks. In >Your< Iron Syrup group, several markers of iron deficiency, such as serum iron concentration, transferrin saturation and ferritin level were significantly improved in both female and male mice. Fe-sulphate induced similar responses, except that it did not significantly increase iron serum in females and serum ferritin in both sexes. Fe-sulphate significantly increased liver-iron content which >Your< Iron Syrup did not. Transcription of Hamp and selected inflammatory genes in the liver was comparable between the two supplementation groups and with the Control diet group. Some sex-specific effects were noted, which were more pronounced and less variable in males. In conclusion, >Your< Iron Syrup was efficient, comparable and in some parameters superior to Fe-sulphate in improving iron-related parameters without inducing a response of selected liver inflammation markers in a mouse model of diet-induced iron deficiency.

Keywords

pomanjkanje železa;železo;prehranski dodatki;laboratorijske miši;

Data

Language:	English
Year of publishing:	2021
Typology:	1.01 - Original Scientific Article
Organization:	UL BF - Biotechnical Faculty
UDC:	612
COBISS:	61018627
ISSN:	2079-7737
Views:	167
Downloads:	45
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	pomanjkanje železa;železo;prehranski dodatki;laboratorijske miši;
Type (COBISS):	Article
Pages:	str. 1-21
Volume:	ǂVol. ǂ10
Issue:	ǂno. ǂ5
Chronology:	22. apr. 2021
DOI:	10.3390/biology10050357
ID:	14704338