Supplementation with >Your< Iron Syrup corrects iron status in a mouse model of diet-induced iron deficiency

Tatjana Pirman (Avtor), Ajda Lenardič (Avtor), Alenka Nemec Svete (Avtor), Simon Horvat (Avtor)

Povzetek

The objective of this study was to compare the effects of >Your< Iron Syrup, a novel oral liquid iron-containing food supplement, with the commonly prescribed iron sulphate (Fe-sulphate) in a mouse model of diet-induced iron deficiency. Standard inbred BALB/cOlaHsd mice were fed low-iron diet for 11 weeks to induce significant decrease in blood haemoglobin and haematocrit and were then supplemented by gavage with either >Your< Iron Syrup or Fe-sulphate for two weeks. In >Your< Iron Syrup group, several markers of iron deficiency, such as serum iron concentration, transferrin saturation and ferritin level were significantly improved in both female and male mice. Fe-sulphate induced similar responses, except that it did not significantly increase iron serum in females and serum ferritin in both sexes. Fe-sulphate significantly increased liver-iron content which >Your< Iron Syrup did not. Transcription of Hamp and selected inflammatory genes in the liver was comparable between the two supplementation groups and with the Control diet group. Some sex-specific effects were noted, which were more pronounced and less variable in males. In conclusion, >Your< Iron Syrup was efficient, comparable and in some parameters superior to Fe-sulphate in improving iron-related parameters without inducing a response of selected liver inflammation markers in a mouse model of diet-induced iron deficiency.

Ključne besede

pomanjkanje železa;železo;prehranski dodatki;laboratorijske miši;

Podatki

Jezik:	Angleški jezik
Leto izida:	2021
Tipologija:	1.01 - Izvirni znanstveni članek
Organizacija:	UL BF - Biotehniška fakulteta
UDK:	612
COBISS:	61018627
ISSN:	2079-7737
Št. ogledov:	167
Št. prenosov:	45
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	pomanjkanje železa;železo;prehranski dodatki;laboratorijske miši;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-21
Letnik:	ǂVol. ǂ10
Zvezek:	ǂno. ǂ5
Čas izdaje:	22. apr. 2021
DOI:	10.3390/biology10050357
ID:	14704338