Tamás Pivarcsik (Author), Gábor Tóth (Author), Nikoletta Szemerédi (Author), Anita Bogdanov (Author), Gabriella Spengler (Author), Jakob Kljun (Author), Jerneja Kladnik (Author), Iztok Turel (Author), Éva A. Enyedy (Author)

Abstract

In this work, the various biological activities of eight organoruthenium(II) complexes were evaluated to reveal correlations with their stability and reactivity in aqueous media. Complexes with general formula [Ru(η$^6$-p-cymene)(X,Y)(Z)] were prepared, where (X,Y) represents either an O,Oligand (β-diketone), N,O-ligand (8-hydroxyquinoline) or O,S-pyrithione-type ligands (pyrithione = 1-hydroxypyridine-2(1H)-thione) with Cl$^−$ or 1,3,5-triaza-7-phosphaadamantane (PTA) as a co-ligand (Z). The tested complexes inhibit the chlamydial growth on HeLa cells, and one of the complexes inhibits the growth of the human herpes simplex virus-2. The chlorido complexes with N,O- and O,S-ligands displayed strong antibacterial activity on Gram-positive strains including the resistant S. aureus (MRSA) and were cytotoxic in adenocarcinoma cell lines. Effect of the structural variation on the biological properties and solution stability was clearly revealed. The decreased bioactivity of the β-diketone complexes can be related to their lower stability in solution. In contrast, the O,Spyrithione-type complexes are highly stable in solution and the complexation prevents the oxidation of the O,S-ligands. Comparing the binding of PTA and the chlorido co-ligands, it can be concluded that PTA is generally more strongly coordinated to ruthenium, which at the same time decreased the reactivity of complexes with human serum albumin or 1-methylimidazole as well as diminished their bioactivity.

Keywords

rutenij;organorutenijevi kompleksi;ligandi;kemijske lastnosti;biološka aktivnost;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL FKKT - Faculty of Chemistry and Chemical Technology
UDC: 546.96:547.8
COBISS: 65179139 Link will open in a new window
ISSN: 1424-8247
Views: 112
Downloads: 44
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Other data

Secondary language: Slovenian
Secondary keywords: rutenij;organorutenijevi kompleksi;ligandi;kemijske lastnosti;biološka aktivnost;
Type (COBISS): Article
Pages: str. 1-24
Volume: ǂVol. ǂ14
Issue: ǂiss. ǂ6
Chronology: Jun. 2021
DOI: 10.3390/ph14060518
ID: 14751396