Jerneja Kladnik (Avtor), James P. C. Coverdale (Avtor), Jakob Kljun (Avtor), Hilke Burmeister (Avtor), Petra Lippman (Avtor), Francesca G. Ellis (Avtor), Alan M. Jones (Avtor), Ingo Ott (Avtor), Isolda Romero-Canelón (Avtor), Iztok Turel (Avtor)

Povzetek

Drug resistance to existing anticancer agents is a growing clinical concern, with many first line treatments showing poor efficacy in treatment plans of some cancers. Resistance to platinum agents, such as cisplatin, is particularly prevalent in the treatment of ovarian cancer, one of the most common cancers amongst women in the developing world. Therefore, there is an urgent need to develop next generation of anticancer agents which can overcome resistance to existing therapies. We report a new series of organoruthenium(II) complexes bearing structurally modified pyrithione ligands with extended aromatic scaffold, which overcome platinum and adriamycin resistance in human ovarian cancer cells. The mechanism of action of such complexes appears to be unique from that of cisplatin, involving G$_1$ cell cycle arrest without generation of cellular ROS, as is typically associated with similar ruthenium complexes. The complexes inhibit the enzyme thioredoxin reductase (TrxR) in a model system and reduce cell motility towards wound healing. Importantly, this work highlights further development in our understanding of the multi-targeting mechanism of action exhibited by transition metal complexes.

Ključne besede

rutenij;organorutenijevi kompleksi;piritioni;rak jajčnikov;ruthenium;pyrithione;resistance to chemotherapy;cancer;ovarian;thioredoxin;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL FKKT - Fakulteta za kemijo in kemijsko tehnologijo
UDK: 546.96:547.8:618.11-006
COBISS: 64129539 Povezava se bo odprla v novem oknu
ISSN: 2072-6694
Št. ogledov: 121
Št. prenosov: 45
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: rutenij;organorutenijevi kompleksi;piritioni;rak jajčnikov;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-21
Letnik: ǂVol. ǂ13
Zvezek: ǂiss. ǂ10
Čas izdaje: May 2021
DOI: 10.3390/cancers13102493
ID: 14759897