prediction of outcome based on DCE-MRI measurements in patients undergoing cytotoxic chemotherapy
Martina Vivoda Tomšič (Author), Peter Korošec (Author), Viljem Kovač (Author), Sotirios Bisdas (Author), Katarina Šurlan Popović (Author)

Abstract

The malignant pleural mesothelioma (MPM) response rate to chemotherapy is low. The identification of imaging biomarkers that could help guide the most effective therapy approach for individual patients is highly desirable. Our aim was to investigate the dynamic contrast-enhanced (DCE) MR parameters as predictors for progression-free (PFS) and overall survival (OS) in patients with MPM treated with cisplatin-based chemotherapy. Methods: Thirty-two consecutive patients with MPM were enrolled in this prospective study. Pretreatment and intratreatment DCE-MRI were scheduled in each patient. The DCE parameters were analyzed using the extended Tofts (ET) and the adiabatic approximation tissue homogeneity (AATH) model. Comparison analysis, logistic regression and ROC analysis were used to identify the predictors for the patient's outcome. Results: Patients with higher pretreatment ET and AATH-calculated Ktrans and ve values had longer OS (P≤.006). Patients with a more prominent reduction in ET-calculated Ktrans and kep values during the early phase of chemotherapy had longer PFS (P =.008). No parameter was identified to predict PFS. Pre-treatment ET-calculated Ktrans was found to be an independent predictive marker for longer OS (P=.02) demonstrating the most favourable discrimination performance compared to other DCE parameters with an estimated sensitivity of 89% and specificity of 78% (AUC 0.9, 95% CI 0.74-0.98, cut off > 0.08 min-1). Conclusions: In the present study, higher pre-treatment ET-calculated Ktrans values were associated with longer OS. The results suggest that DCE-MRI might provide additional information for identifying MPM patients that may respond to chemotherapy.

Keywords

cisplatin;slikanje z magnetno resonanco;mezoteliom;magnetic resonance imaging;mesothelioma;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: OI - Institute of Oncology
Publisher: Springer Nature
UDC: 616-07
COBISS: 99703043 Link will open in a new window
ISSN: 1471-2407
Views: 304
Downloads: 148
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Other data

Secondary keywords: cisplatin;slikanje z magnetno resonanco;mezoteliom;
Source comment: Nasl. z nasl. zaslona; Opis vira z dne 2. 2. 2022;
Pages: str. 191-1-191-11
Volume: ǂVol. ǂ22
Issue: ǂiss. ǂ1
Chronology: 2022
DOI: 10.1186/s12885-022-09277-x
ID: 14957357