Maja Potokar (Author), Jernej Jorgačevski (Author)

Abstract

Plectin, a high-molecular-mass cytolinker, is abundantly expressed in the central nervous system (CNS). Currently, a limited amount of data about plectin in the CNS prevents us from seeing the complete picture of how plectin affects the functioning of the CNS as a whole. Yet, by analogy to its role in other tissues, it is anticipated that, in the CNS, plectin also functions as the key cytoskeleton interlinking molecule. Thus, it is likely involved in signalling processes, thereby affecting numerous fundamental functions in the brain and spinal cord. Versatile direct and indirect interactions of plectin with cytoskeletal filaments and enzymes in the cells of the CNS in normal physiological and in pathologic conditions remain to be fully addressed. Several pathologies of the CNS related to plectin have been discovered in patients with plectinopathies. However, in view of plectin as an integrator of a cohesive mesh of cellular proteins, it is important that the role of plectin is also considered in other CNS pathologies. This review summarizes the current knowledge of plectin in the CNS, focusing on plectin isoforms that have been detected in the CNS, along with its expression profile and distribution alongside diverse cytoskeleton filaments in CNS cell types. Considering that the bidirectional communication between neurons and glial cells, especially astrocytes, is crucial for proper functioning of the CNS, we place particular emphasis on the known roles of plectin in neurons, and we propose possible roles of plectin in astrocytes.

Keywords

plektin;centralni živčni sistem;astrociti;plectin;central nervous system;astrocytes;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616-092
COBISS: 76345603 Link will open in a new window
ISSN: 2073-4409
Views: 114
Downloads: 29
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Other data

Secondary language: Slovenian
Secondary keywords: plektin;centralni živčni sistem;astrociti;
Type (COBISS): Article
Pages: str. 1-17
Volume: ǂVol. ǂ10
Issue: ǂiss. ǂ9
Chronology: 2021
DOI: 10.3390/cells10092353
ID: 15023695