Špela Gruden (Author), Nataša Poklar Ulrih (Author)

Abstract

Lactoferrins are an iron-binding glycoprotein that have important protective roles in the mammalian body through their numerous functions, which include antimicrobial, antitumor, anti-inflammatory, immunomodulatory, and antioxidant activities. Among these, their antimicrobial activity has been the most studied, although the mechanism behind antimicrobial activities remains to be elucidated. Thirty years ago, the first lactoferrin-derived peptide was isolated and showed higher antimicrobial activity than the native lactoferrin lactoferricin. Since then, numerous studies have investigated the antimicrobial potencies of lactoferrins, lactoferricins, and other lactoferrin-derived peptides to better understand their antimicrobial activities at the molecular level. This review defines the current antibacterial, antiviral, antifungal, and antiparasitic activities of lactoferrins, lactoferricins, and lactoferrin-derived peptides. The primary focus is on their different mechanisms of activity against bacteria, viruses, fungi, and parasites. The role of their structure, amino-acid composition, conformation, charge, hydrophobicity, and other factors that affect their mechanisms of antimicrobial activity are also reviewed.

Keywords

bioaktivni peptidi;laktoferin;protimikrobno delovanje;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL BF - Biotechnical Faculty
UDC: 577.112:579.2
COBISS: 81567491 Link will open in a new window
ISSN: 1422-0067
Views: 113
Downloads: 36
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Other data

Secondary language: Slovenian
Secondary keywords: bioaktivni peptidi;laktoferin;protimikrobno delovanje;
Type (COBISS): Article
Pages: str. 1-29
Volume: ǂVol. ǂ22
Issue: ǂiss. ǂ20
Chronology: 2021
DOI: 10.3390/ijms222011264
ID: 15088785