Luka Roškar (Author), Irena Roškar (Author), Tea Lanišnik-Rižner (Author), Špela Smrkolj (Author)

Abstract

Endometrial cancer (EC) is the most frequent gynecological malignancy in developed countries and requires a relatively invasive diagnostic evaluation and operative therapy as the primary therapeutic approach. Angiogenesis is one of the main processes needed for cancer growth and spread. The production of angiogenic factors (AFs) appears early in the process of carcinogenesis. The detection of AFs in plasma and tissue and a better understanding of the angiogenic properties of EC may contribute not only to earlier but also more specific diagnosis and consequently tailored and individual therapeutic approaches. AFs and their receptors also have high potential as binding sites for targeted cancer therapy. In this review, we discuss angiogenesis in EC and the characteristics of the AFs that most contribute to angiogenesis in EC. We also highlight therapeutic strategies that target angiogenesis as potential EC therapy.

Keywords

endometrial cancer;angiogenesis;biomarkers;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616-006
COBISS: 90507523 Link will open in a new window
ISSN: 2218-273X
Views: 85
Downloads: 26
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: rak endometrija;angiogeneza;biomarkerji;
Type (COBISS): Article
Pages: str. [1]-14
Volume: ǂVol. ǂ12
Issue: ǂiss. ǂ1
Chronology: 2022
DOI: 10.3390/biom12010007
ID: 15406895