Luka Roškar (Avtor), Irena Roškar (Avtor), Tea Lanišnik-Rižner (Avtor), Špela Smrkolj (Avtor)

Povzetek

Endometrial cancer (EC) is the most frequent gynecological malignancy in developed countries and requires a relatively invasive diagnostic evaluation and operative therapy as the primary therapeutic approach. Angiogenesis is one of the main processes needed for cancer growth and spread. The production of angiogenic factors (AFs) appears early in the process of carcinogenesis. The detection of AFs in plasma and tissue and a better understanding of the angiogenic properties of EC may contribute not only to earlier but also more specific diagnosis and consequently tailored and individual therapeutic approaches. AFs and their receptors also have high potential as binding sites for targeted cancer therapy. In this review, we discuss angiogenesis in EC and the characteristics of the AFs that most contribute to angiogenesis in EC. We also highlight therapeutic strategies that target angiogenesis as potential EC therapy.

Ključne besede

endometrial cancer;angiogenesis;biomarkers;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616-006
COBISS: 90507523 Povezava se bo odprla v novem oknu
ISSN: 2218-273X
Št. ogledov: 85
Št. prenosov: 26
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: rak endometrija;angiogeneza;biomarkerji;
Vrsta dela (COBISS): Članek v reviji
Strani: str. [1]-14
Letnik: ǂVol. ǂ12
Zvezek: ǂiss. ǂ1
Čas izdaje: 2022
DOI: 10.3390/biom12010007
ID: 15406895