problems and solutions
Alen Gabrič (Author), Žiga Hodnik (Author), Stane Pajk (Author)

Abstract

Oxidation is the second most common degradation pathway for pharmaceuticals, after hydrolysis. However, in contrast to hydrolysis, oxidation is mechanistically more complex and produces a wider range of degradation products; oxidation is thus harder to control. The propensity of a drug towards oxidation is established during forced degradation studies. However, a more realistic insight into degradation in the solid state can be achieved with accelerated studies of mixtures of drugs and excipients, as the excipients are the most common sources of impurities that have the potential to initiate oxidation of a solid drug product. Based on the results of these studies, critical parameters can be identified and appropriate measures can be taken to avoid the problems that oxidation poses to the quality of a drug product. This article reviews the most common types of oxidation mechanisms, possible sources of reactive oxygen species, and how to minimize the oxidation of a solid drug product based on a well-planned accelerated study.

Keywords

nečistoče;novi oksidativni stresorji;testiranje oksidativnega stresa;peroksidi;oxidation;peroxides;impurities;new oxidative stressors;oxidative stress testing;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL FFA - Faculty of Pharmacy
UDC: 542.943:615
COBISS: 100590851 Link will open in a new window
ISSN: 1999-4923
Views: 79
Downloads: 20
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: Zdravila;Oksidacija;Oksidativni stres;
Type (COBISS): Article
Pages: str. 1-19
Volume: ǂVol. ǂ14
Issue: ǂiss. ǂ2
Chronology: 2022
DOI: 10.3390/pharmaceutics14020325
ID: 15437278