Abstract
Preterm birth (before 37 weeks gestation) accounts for ~10% of births worldwide and
remains one of the leading causes of death in children under 5 years of age. Preterm born adults have
been consistently shown to be at an increased risk for chronic disorders including cardiovascular,
endocrine/metabolic, respiratory, renal, neurologic, and psychiatric disorders that result in increased
death risk. Oxidative stress was shown to be an important risk factor for hypertension, metabolic
syndrome and lung disease (reduced pulmonary function, long-term obstructive pulmonary disease,
respiratory infections, and sleep disturbances). The aim of this study was to explore the differences
between preterm and full-term male participants’ levels of urine and fecal proton nuclear magnetic
resonance ($^1$H-NMR) metabolomes, during rest and exercise in normoxia and hypoxia and to assess
general differences in human gut-microbiomes through metagenomics at the level of taxonomy,
diversity, functional genes, enzymatic reactions, metabolic pathways and predicted gut metabolites.
Significant differences existed between the two groups based on the analysis of $^1$H-NMR urine and
fecal metabolomes and their respective metabolic pathways, enabling the elucidation of a complex
set of microbiome related metabolic biomarkers, supporting the idea of distinct host-microbiome
interactions between the two groups and enabling the efficient classification of samples; however,
this could not be directed to specific taxonomic characteristics.
Keywords
biokemija;metabolomika;prezgodnje rojstvo;odrasli moški;biomarkerji;
Data
Language: |
English |
Year of publishing: |
2022 |
Typology: |
1.01 - Original Scientific Article |
Organization: |
UL BF - Biotechnical Faculty |
UDC: |
612 |
COBISS: |
111333123
|
ISSN: |
2218-1989 |
Views: |
171 |
Downloads: |
48 |
Average score: |
0 (0 votes) |
Metadata: |
|
Other data
Secondary language: |
English |
Secondary keywords: |
biokemija;metabolomika;prezgodnje rojstvo;odrasli moški;biomarkerji; |
Type (COBISS): |
Article |
Pages: |
str. 1-22 |
Volume: |
ǂno. ǂ6 |
Issue: |
ǂart. ǂ536 |
Chronology: |
2022 |
DOI: |
10.3390/metabo12060536 |
ID: |
15940655 |