Leon Deutsch (Avtor), Tadej Debevec (Avtor), Grégoire P. Millet (Avtor), Damjan Osredkar (Avtor), Simona Konda (Avtor), Robert Šket (Avtor), Boštjan Murovec (Avtor), Minca Mramor (Avtor), Janez Plavec (Avtor), Blaž Stres (Avtor)

Povzetek

Preterm birth (before 37 weeks gestation) accounts for ~10% of births worldwide and remains one of the leading causes of death in children under 5 years of age. Preterm born adults have been consistently shown to be at an increased risk for chronic disorders including cardiovascular, endocrine/metabolic, respiratory, renal, neurologic, and psychiatric disorders that result in increased death risk. Oxidative stress was shown to be an important risk factor for hypertension, metabolic syndrome and lung disease (reduced pulmonary function, long-term obstructive pulmonary disease, respiratory infections, and sleep disturbances). The aim of this study was to explore the differences between preterm and full-term male participants’ levels of urine and fecal proton nuclear magnetic resonance ($^1$H-NMR) metabolomes, during rest and exercise in normoxia and hypoxia and to assess general differences in human gut-microbiomes through metagenomics at the level of taxonomy, diversity, functional genes, enzymatic reactions, metabolic pathways and predicted gut metabolites. Significant differences existed between the two groups based on the analysis of $^1$H-NMR urine and fecal metabolomes and their respective metabolic pathways, enabling the elucidation of a complex set of microbiome related metabolic biomarkers, supporting the idea of distinct host-microbiome interactions between the two groups and enabling the efficient classification of samples; however, this could not be directed to specific taxonomic characteristics.

Ključne besede

biokemija;metabolomika;prezgodnje rojstvo;odrasli moški;biomarkerji;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL BF - Biotehniška fakulteta
UDK: 612
COBISS: 111333123 Povezava se bo odprla v novem oknu
ISSN: 2218-1989
Št. ogledov: 171
Št. prenosov: 48
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Angleški jezik
Sekundarne ključne besede: biokemija;metabolomika;prezgodnje rojstvo;odrasli moški;biomarkerji;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-22
Letnik: ǂno. ǂ6
Zvezek: ǂart. ǂ536
Čas izdaje: 2022
DOI: 10.3390/metabo12060536
ID: 15940655