Insight into the complexity of male infertility

ǂa ǂmulti-omics review

Rebeka Podgrajšek (Avtor), Alenka Hodžić (Avtor), Martin Štimpfel (Avtor), Tanja Kunej (Avtor), Borut Peterlin (Avtor)

Povzetek

Male infertility is a reproductive disorder, accounting for 40–50% of infertility. Currently, in about 70% of infertile men, the cause remains unknown. With the introduction of novel omics and advancement in high-throughput technology, potential biomarkers are emerging. The main purpose of our work was to overview different aspects of omics approaches in association with idiopathic male infertility and highlight potential genes, transcripts, non-coding RNA, proteins, and metabolites worth further exploring. Using the Gene Ontology (GO) analysis, we aimed to compare enriched GO terms from each omics approach and determine their overlapping. A PubMed database screening for the literature published between February 2014 and June 2022 was performed using the keywords: male infertility in association with different omics approaches: genomics, epigenomics, transcriptomics, ncRNAomics, proteomics, and metabolomics. A GO enrichment analysis was performed using the Enrichr tool. We retrieved 281 global studies: 171 genomics (DNA level), 21 epigenomics (19 of methylation and two histone residue modifications), 15 transcriptomics, 31 non-coding RNA, 29 proteomics, two protein posttranslational modification, and 19 metabolomics studies. Gene ontology comparison showed that different omics approaches lead to the identification of different molecular factors and that the corresponding GO terms, obtained from different omics approaches, do not overlap to a larger extent. With the integration of novel omics levels into the research of idiopathic causes of male infertility, using multi-omic systems biology approaches, we will be closer to finding the potential biomarkers and consequently becoming aware of the entire spectrum of male infertility, their cause, prognosis, and potential treatment.

Ključne besede

genetika;genomika;več-omike;biomarkerji;moški;neplodnost;

Podatki

Jezik:	Angleški jezik
Leto izida:	2024
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UL BF - Biotehniška fakulteta
UDK:	575
COBISS:	190110723
ISSN:	1939-6368
Št. ogledov:	98
Št. prenosov:	20
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	genetika;genomika;večomike;biomarkerji;moški;neplodnost;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 73-90
Letnik:	ǂVol. ǂ70
Zvezek:	ǂno. ǂ1
Čas izdaje:	2024
DOI:	10.1080/19396368.2024.2317804
ID:	23281737