Cell death due to electroporation

ǂa ǂreview

Tina Batista Napotnik (Author), Tamara Polajžer (Author), Damijan Miklavčič (Author)

Abstract

Exposure of cells to high voltage electric pulses increases transiently membrane permeability through membrane electroporation. Electroporation can be reversible and is used in gene transfer and enhanced drug delivery but can also lead to cell death. Electroporation resulting in cell death (termed as irreversible electroporation) has been successfully used as a new non-thermal ablation method of soft tissue such as tumours or arrhythmogenic heart tissue. Even though the mechanisms of cell death can influence the outcome of electroporation-based treatments due to use of different electric pulse parameters and conditions, these are not elucidated yet. We review the mechanisms of cell death after electroporation reported in literature, cell injuries that may lead to cell death after electroporation and membrane repair mechanisms involved. The knowledge of membrane repair and cell death mechanisms after cell exposure to electric pulses, targets of electric field in cells need to be identified to optimize existing and develop of new electroporation-based techniques used in medicine, biotechnology, and food technology.

Keywords

apoptoza;celična smrt;poškodba celice;elektroporacija;celjenje membrane;nekroptoza;nekroza;piroptoza;apoptosis;cell death;cell injury;electroporation;membrane repair;necroptosis;necrosis;pyroptosis;

Data

Language:	English
Year of publishing:	2021
Typology:	1.02 - Review Article
Organization:	UL FE - Faculty of Electrical Engineering
UDC:	577:602.621
COBISS:	69133827
ISSN:	1567-5394
Views:	60
Downloads:	20
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	apoptoza;celična smrt;poškodba celice;elektroporacija;celjenje membrane;nekroptoza;nekroza;piroptoza;
Type (COBISS):	Article
Pages:	str. 1-18
Volume:	ǂVol. ǂ141
Issue:	107871
Chronology:	Oct. 2021
DOI:	10.1016/j.bioelechem.2021.107871
ID:	16120577