ǂa ǂreview
Tina Batista Napotnik (Avtor), Tamara Polajžer (Avtor), Damijan Miklavčič (Avtor)

Povzetek

Exposure of cells to high voltage electric pulses increases transiently membrane permeability through membrane electroporation. Electroporation can be reversible and is used in gene transfer and enhanced drug delivery but can also lead to cell death. Electroporation resulting in cell death (termed as irreversible electroporation) has been successfully used as a new non-thermal ablation method of soft tissue such as tumours or arrhythmogenic heart tissue. Even though the mechanisms of cell death can influence the outcome of electroporation-based treatments due to use of different electric pulse parameters and conditions, these are not elucidated yet. We review the mechanisms of cell death after electroporation reported in literature, cell injuries that may lead to cell death after electroporation and membrane repair mechanisms involved. The knowledge of membrane repair and cell death mechanisms after cell exposure to electric pulses, targets of electric field in cells need to be identified to optimize existing and develop of new electroporation-based techniques used in medicine, biotechnology, and food technology.

Ključne besede

apoptoza;celična smrt;poškodba celice;elektroporacija;celjenje membrane;nekroptoza;nekroza;piroptoza;apoptosis;cell death;cell injury;electroporation;membrane repair;necroptosis;necrosis;pyroptosis;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL FE - Fakulteta za elektrotehniko
UDK: 577:602.621
COBISS: 69133827 Povezava se bo odprla v novem oknu
ISSN: 1567-5394
Št. ogledov: 60
Št. prenosov: 20
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: apoptoza;celična smrt;poškodba celice;elektroporacija;celjenje membrane;nekroptoza;nekroza;piroptoza;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-18
Letnik: ǂVol. ǂ141
Zvezek: 107871
Čas izdaje: Oct. 2021
DOI: 10.1016/j.bioelechem.2021.107871
ID: 16120577