Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin

Martina Mravinec (Author), Gregor Bajc (Author), Matej Butala (Author)

Abstract

The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction of RdRp with drugs in real time. We monitored the effect of favipiravir, ribavirin, sofosbuvir triphosphate PSI-7409 and suramin on RdRp binding to RNA immobilized on the chip. Suramin precluded interaction of RdRp with RNA and even displaced RdRp from RNA.

Keywords

površinska plazmonska resonanca;suramin;SARS-CoV-2;Covid-19;

Data

Language:	English
Year of publishing:	2021
Typology:	1.01 - Original Scientific Article
Organization:	UL BF - Biotechnical Faculty
UDC:	577.2
COBISS:	76436739
ISSN:	0166-0934
Views:	37
Downloads:	28
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	površinska plazmonska resonanca;suramin;SARS-CoV-2;covid-19;
Type (COBISS):	Article
Pages:	str. 1-7, [in press]
Volume:	ǂVol. ǂ
Issue:	ǂiss. ǂ
Chronology:	2021
DOI:	10.1016/j.jviromet.2021.114283
ID:	16252545