Surface plasmon resonance approach to study drug interactions with SARS-CoV-2 RNA-dependent RNA polymerase highlights treatment potential of suramin

Martina Mravinec (Avtor), Gregor Bajc (Avtor), Matej Butala (Avtor)

Povzetek

The SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) is essential for virus replication, therefore it is a promising drug target. Here we present a surface plasmon resonance approach to study the interaction of RdRp with drugs in real time. We monitored the effect of favipiravir, ribavirin, sofosbuvir triphosphate PSI-7409 and suramin on RdRp binding to RNA immobilized on the chip. Suramin precluded interaction of RdRp with RNA and even displaced RdRp from RNA.

Ključne besede

površinska plazmonska resonanca;suramin;SARS-CoV-2;Covid-19;

Podatki

Jezik:	Angleški jezik
Leto izida:	2021
Tipologija:	1.01 - Izvirni znanstveni članek
Organizacija:	UL BF - Biotehniška fakulteta
UDK:	577.2
COBISS:	76436739
ISSN:	0166-0934
Št. ogledov:	37
Št. prenosov:	28
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	površinska plazmonska resonanca;suramin;SARS-CoV-2;covid-19;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-7, [in press]
Letnik:	ǂVol. ǂ
Zvezek:	ǂiss. ǂ
Čas izdaje:	2021
DOI:	10.1016/j.jviromet.2021.114283
ID:	16252545