Cell models for Alzheimer’s and Parkinson’s disease

ǂat ǂthe interface of biology and drug discovery

Sandra Cetin (Author), Damijan Knez (Author), Stanislav Gobec (Author), Janko Kos (Author), Anja Pišlar (Author)

Abstract

Neurodegenerative diseases are severely debilitating conditions characterized primarily by progressive neuronal loss and impairment of the nervous system. Alzheimer’s and Parkinson’s diseases are the most common neurodegenerative disorders, and their impact is increasing as average life expectancy increases worldwide. Although the underlying mechanisms of both progressive diseases have been extensively studied, we still lack a comprehensive understanding of the molecular basis of both diseases. Current therapeutic options do not slow the progression of the diseases and only provide symptom relief. Cell models that resemble the characteristics of the disease in question are important in drug discovery projects because they provide information about the therapeutic benefits of drugs under development. Here, we review current in vitro cell models used to study the molecular basis of Alzheimer’s and Parkinson’s disease focusing on their potential for discovering of disease-modifying therapeutics to combat neurodegenerative diseases. We discuss phenotypic screening as an important approach for identifying novel therapeutic molecules. Advances in the development of cell-based assays for drug discovery are discussed, ranging from simple monoculture cell models to high-throughput three-dimensional cell models. Finally, we critically present the limitations of cell models and the caveats encountered in drug discovery to find effective treatment for neurodegenerative diseases.

Keywords

neurodegenerative diseases;cell models;cytotoxicity assays;drug discovery;drug screening;

Data

Language:	English
Year of publishing:	2022
Typology:	1.02 - Review Article
Organization:	UL FFA - Faculty of Pharmacy
UDC:	615.4:54:616.831-003.8
COBISS:	105487619
ISSN:	1950-6007
Views:	51
Downloads:	23
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	Slovenian
Secondary keywords:	nevrodegenerativne bolezni;celični modeli;preskusi citotoksičnosti;odkrivanje zdravil;Nevrodegenerativne bolezni;Alzheimerjeva bolezen;Parkinsonova bolezen;Farmacevtska kemija;
Type (COBISS):	Article
Pages:	str. 1-11
Issue:	ǂVol. ǂ149
Chronology:	2022
DOI:	10.1016/j.biopha.2022.112924
ID:	16317304