Humna Liaqat (Author), Amna Parveen (Author), Sun Yeou Kim (Author)

Abstract

Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.

Keywords

mikrobiologija;os črevesje možgani;depresija;BDNF;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL BF - Biotechnical Faculty
UDC: 579
COBISS: 132209155 Link will open in a new window
ISSN: 1422-0067
Views: 13
Downloads: 3
Average score: 0 (0 votes)
Metadata: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Other data

Secondary language: Slovenian
Secondary keywords: mikrobiologija;os črevesje možgani;depresija;BDNF;
Type (COBISS): Article
Pages: str. 1-30
Volume: ǂno. ǂ23
Issue: ǂart. ǂ14968
Chronology: 2022
DOI: 10.3390/ijms232314968
ID: 17539248