Antidepressive effect of natural products and their derivatives targeting BDNF-TrkB in gut–brain axis

Humna Liaqat (Avtor), Amna Parveen (Avtor), Sun Yeou Kim (Avtor)

Povzetek

Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.

Ključne besede

mikrobiologija;os črevesje možgani;depresija;BDNF;

Podatki

Jezik:	Angleški jezik
Leto izida:	2022
Tipologija:	1.02 - Pregledni znanstveni članek
Organizacija:	UL BF - Biotehniška fakulteta
UDK:	579
COBISS:	132209155
ISSN:	1422-0067
Št. ogledov:	13
Št. prenosov:	3
Ocena:	0 (0 glasov)
Metapodatki:

Ostali podatki

Sekundarni jezik:	Slovenski jezik
Sekundarne ključne besede:	mikrobiologija;os črevesje možgani;depresija;BDNF;
Vrsta dela (COBISS):	Članek v reviji
Strani:	str. 1-30
Letnik:	ǂno. ǂ23
Zvezek:	ǂart. ǂ14968
Čas izdaje:	2022
DOI:	10.3390/ijms232314968
ID:	17539248