ǂa ǂsystematic review
Evangelia Eirini Tsermpini (Author), Una Glamočlija (Author), Fulden Ulucan-Karnak (Author), Sara Redenšek (Author), Vita Dolžan (Author)

Abstract

The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease’s progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx of immune cells to the site of infection is marked by the increase in reactive oxygen and nitrogen species. Our article aims to highlight the critical role of oxidative stress in the emergence and severity of COVID-19 and, more importantly, to shed light on the underlying molecular and genetic mechanisms. We have reviewed the available literature and clinical trials to extract the relevant genetic variants within the oxidative stress pathway associated with COVID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine.

Keywords

COVID-19;oksidativni stres;genetika;oxidative stress;genetics;

Data

Language: English
Year of publishing:
Typology: 1.02 - Review Article
Organization: UL MF - Faculty of Medicine
UDC: 616.9
COBISS: 118709507 Link will open in a new window
ISSN: 2076-3921
Views: 18
Downloads: 3
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: COVID-19;oksidativni stres;genetika;
Type (COBISS): Article
Pages: str. 1-39
Volume: ǂVol. ǂ11
Issue: ǂiss. ǂ8
Chronology: 2022
DOI: 10.3390/antiox11081609
ID: 18583955