ǂa ǂsystematic review
Evangelia Eirini Tsermpini (Avtor), Una Glamočlija (Avtor), Fulden Ulucan-Karnak (Avtor), Sara Redenšek (Avtor), Vita Dolžan (Avtor)

Povzetek

The coronavirus disease (COVID-19) pandemic is a leading global health and economic challenge. What defines the disease’s progression is not entirely understood, but there are strong indications that oxidative stress and the defense against reactive oxygen species are crucial players. A big influx of immune cells to the site of infection is marked by the increase in reactive oxygen and nitrogen species. Our article aims to highlight the critical role of oxidative stress in the emergence and severity of COVID-19 and, more importantly, to shed light on the underlying molecular and genetic mechanisms. We have reviewed the available literature and clinical trials to extract the relevant genetic variants within the oxidative stress pathway associated with COVID-19 and the anti-oxidative therapies currently evaluated in the clinical trials for COVID-19 treatment, in particular clinical trials on glutathione and N-acetylcysteine.

Ključne besede

COVID-19;oksidativni stres;genetika;oxidative stress;genetics;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.02 - Pregledni znanstveni članek
Organizacija: UL MF - Medicinska fakulteta
UDK: 616.9
COBISS: 118709507 Povezava se bo odprla v novem oknu
ISSN: 2076-3921
Št. ogledov: 18
Št. prenosov: 3
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: COVID-19;oksidativni stres;genetika;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-39
Letnik: ǂVol. ǂ11
Zvezek: ǂiss. ǂ8
Čas izdaje: 2022
DOI: 10.3390/antiox11081609
ID: 18583955