Tanja Zidarič (Author), Kristijan Skok (Author), Kristjan Orthaber (Author), Matevž Pristovnik (Author), Lidija Gradišnik (Author), Tina Maver (Author), Uroš Maver (Author)

Abstract

This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief.

Keywords

wound dressings;pain relief;superparamagnetic nanoparticles;methacrylate;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM MF - Faculty of Medicine
Publisher: MDPI
UDC: 615.4
COBISS: 146598147 Link will open in a new window
ISSN: 1996-1944
Views: 33
Downloads: 0
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Other data

Secondary language: Slovenian
Secondary keywords: obloge za rane;lajšanje bolečin;superparamagnetni nanodelci;metakrilat;
Type (COBISS): Scientific work
Pages: str. 1-21
Volume: ǂVol. ǂ16
Issue: ǂissue ǂ6, [article no.] 2361
Chronology: 2023
DOI: 10.3390/ma16062361
ID: 23467872