Tanja Zidarič (Avtor), Kristijan Skok (Avtor), Kristjan Orthaber (Avtor), Matevž Pristovnik (Avtor), Lidija Gradišnik (Avtor), Tina Maver (Avtor), Uroš Maver (Avtor)

Povzetek

This study presents an innovative wound dressing system that offers a highly effective therapeutic solution for treating painful wounds. By incorporating the widely used non-steroidal anti-inflammatory drug diclofenac, we have created an active wound dressing that can provide targeted pain relief with ease. The drug was embedded within a biocompatible matrix composed of polyhydroxyethyl methacrylate and polyhydroxypropyl methacrylate. The multilayer structure of the dressing, which allows for sustained drug release and an exact application, was achieved through the layer-by-layer coating technique and the inclusion of superparamagnetic iron platinum nanoparticles. The multilayered dressings’ physicochemical, structural, and morphological properties were characterised using various methods. The synergistic effect of the incorporated drug molecules and superparamagnetic nanoparticles on the surface roughness and release kinetics resulted in controlled drug release. In addition, the proposed multilayer wound dressings were found to be biocompatible with human skin fibroblasts. Our findings suggest that the developed wound dressing system can contribute to tailored therapeutic strategies for local pain relief.

Ključne besede

wound dressings;pain relief;superparamagnetic nanoparticles;methacrylate;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UM MF - Medicinska fakulteta
Založnik: MDPI
UDK: 615.4
COBISS: 146598147 Povezava se bo odprla v novem oknu
ISSN: 1996-1944
Št. ogledov: 33
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: obloge za rane;lajšanje bolečin;superparamagnetni nanodelci;metakrilat;
Vrsta dela (COBISS): Znanstveno delo
Strani: str. 1-21
Letnik: ǂVol. ǂ16
Zvezek: ǂissue ǂ6, [article no.] 2361
Čas izdaje: 2023
DOI: 10.3390/ma16062361
ID: 23467872