Jan Zmazek (Author), Vladimir Grubelnik (Author), Rene Markovič (Author), Marko Marhl (Author)

Abstract

Type 2 Diabetes Mellitus (T2DM) is a burdensome problem in modern society, and intensive research is focused on better understanding the underlying cellular mechanisms of hormone secretion for blood glucose regulation. T2DM is a bi-hormonal disease, and in addition to 100 years of increasing knowledge about the importance of insulin, the second hormone glucagon, secreted by pancreatic alpha cells, is becoming increasingly important. We have developed a mathematical model for glucagon secretion that incorporates all major metabolic processes of glucose, fatty acids, and glutamine as the most abundant postprandial amino acid in blood. In addition, we consider cAMP signaling in alpha cells. The model predictions quantitatively estimate the relative importance of specific metabolic and signaling pathways and particularly emphasize the important role of glutamine in promoting glucagon secretion, which is in good agreement with known experimental data.

Keywords

sladkorna bolezen;izločanje hormonov;glukoza;aminokisline;ne zaključna dela;diabetes;hormone secretion;glucose;amino acid;cAMP;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UM FNM - Faculty of Natural Sciences and Mathematics
Publisher: MDPI
UDC: 616.379-008.64
COBISS: 105003779 Link will open in a new window
ISSN: 2218-1989
Views: 10
Downloads: 0
Average score: 0 (0 votes)
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Other data

Secondary language: Slovenian
Secondary keywords: Sladkorna bolezen;Hormoni;Glukoza;Aminokisline;
Type (COBISS): Article
Pages: str. 1-15
Volume: ǂVol. ǂ12
Issue: ǂiss. ǂ4
Chronology: 2022
DOI: 10.3390/metabo12040348
ID: 23735419