Jan Zmazek (Avtor), Vladimir Grubelnik (Avtor), Rene Markovič (Avtor), Marko Marhl (Avtor)

Povzetek

Type 2 Diabetes Mellitus (T2DM) is a burdensome problem in modern society, and intensive research is focused on better understanding the underlying cellular mechanisms of hormone secretion for blood glucose regulation. T2DM is a bi-hormonal disease, and in addition to 100 years of increasing knowledge about the importance of insulin, the second hormone glucagon, secreted by pancreatic alpha cells, is becoming increasingly important. We have developed a mathematical model for glucagon secretion that incorporates all major metabolic processes of glucose, fatty acids, and glutamine as the most abundant postprandial amino acid in blood. In addition, we consider cAMP signaling in alpha cells. The model predictions quantitatively estimate the relative importance of specific metabolic and signaling pathways and particularly emphasize the important role of glutamine in promoting glucagon secretion, which is in good agreement with known experimental data.

Ključne besede

sladkorna bolezen;izločanje hormonov;glukoza;aminokisline;ne zaključna dela;diabetes;hormone secretion;glucose;amino acid;cAMP;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UM FNM - Fakulteta za naravoslovje in matematiko
Založnik: MDPI
UDK: 616.379-008.64
COBISS: 105003779 Povezava se bo odprla v novem oknu
ISSN: 2218-1989
Št. ogledov: 10
Št. prenosov: 0
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarni jezik: Slovenski jezik
Sekundarne ključne besede: Sladkorna bolezen;Hormoni;Glukoza;Aminokisline;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 1-15
Letnik: ǂVol. ǂ12
Zvezek: ǂiss. ǂ4
Čas izdaje: 2022
DOI: 10.3390/metabo12040348
ID: 23735419