histopathological and immunohistochemical evaluation with proposed histopathological classification system
Tamara Dolenšek (Author), Tanja Knific (Author), Gustavo A. Ramírez (Author), Kerstin Erles (Author), Hannah E. Mallon (Author), Simon L. Priestnall (Author), Alejandro Suárez-Bonnet (Author)

Abstract

Canine ovarian epithelial tumours (OETs) are currently divided into ovarian adenomas and carcinomas, which are further inconsistently subclassified as papillary or cystic, whereas in human medicine, OETs are subdivided into several subtypes. This study aimed to establish clear morphological features enabling more consistent distinction between benign OETs and ovarian carcinomas (OvCas) as well as defining different histopathological patterns of canine OvCas. Analysis revealed a mitotic count threshold of >2 as a potential criterion for differentiating OvCas from benign OETs. Alongside ovarian adenomas, ovarian borderline tumours were introduced as a distinct category among benign OETs. OvCas exhibited five different histopathological patterns, namely papillary, solid with tubular differentiation, micropapillary, cystic and sarcomatous. Since some OvCas can morphologically overlap with other ovarian tumours, the expression of cytokeratin 7, a cytokeratin expressed in ovarian epithelium, was assessed and proved helpful, although it was not expressed in all cases. Furthermore, we investigated the expression of 14-3-3σ and cyclooxygenase 2 (COX-2). Based on the frequent expression of 14-3-3σ, this marker appears to have a role in canine OETs since it is not expressed in normal canine ovaries. The infrequent expression of COX-2 suggests that it is a poor candidate as a potential therapeutic target in canine OvCas.

Keywords

14-3-3σ protein;canine;CK7;COX-2;ovarian carcinoma;ovarian epithelial tumour;tumour classification;

Data

Language: English
Year of publishing:
Typology: 1.01 - Original Scientific Article
Organization: UL VF - Veterinary Faculty
UDC: 636.09:616
COBISS: 201195267 Link will open in a new window
ISSN: 1532-3129
Views: 51
Downloads: 5
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Other data

Secondary keywords: Pathology;Neoplasms;Dogs;
Type (COBISS): Article
Pages: str. 42-50
Issue: ǂVol. ǂ212
Chronology: 2024
DOI: 10.1016/j.jcpa.2024.05.006
ID: 24599388