histopathological and immunohistochemical evaluation with proposed histopathological classification system
Tamara Dolenšek (Avtor), Tanja Knific (Avtor), Gustavo A. Ramírez (Avtor), Kerstin Erles (Avtor), Hannah E. Mallon (Avtor), Simon L. Priestnall (Avtor), Alejandro Suárez-Bonnet (Avtor)

Povzetek

Canine ovarian epithelial tumours (OETs) are currently divided into ovarian adenomas and carcinomas, which are further inconsistently subclassified as papillary or cystic, whereas in human medicine, OETs are subdivided into several subtypes. This study aimed to establish clear morphological features enabling more consistent distinction between benign OETs and ovarian carcinomas (OvCas) as well as defining different histopathological patterns of canine OvCas. Analysis revealed a mitotic count threshold of >2 as a potential criterion for differentiating OvCas from benign OETs. Alongside ovarian adenomas, ovarian borderline tumours were introduced as a distinct category among benign OETs. OvCas exhibited five different histopathological patterns, namely papillary, solid with tubular differentiation, micropapillary, cystic and sarcomatous. Since some OvCas can morphologically overlap with other ovarian tumours, the expression of cytokeratin 7, a cytokeratin expressed in ovarian epithelium, was assessed and proved helpful, although it was not expressed in all cases. Furthermore, we investigated the expression of 14-3-3σ and cyclooxygenase 2 (COX-2). Based on the frequent expression of 14-3-3σ, this marker appears to have a role in canine OETs since it is not expressed in normal canine ovaries. The infrequent expression of COX-2 suggests that it is a poor candidate as a potential therapeutic target in canine OvCas.

Ključne besede

14-3-3σ protein;canine;CK7;COX-2;ovarian carcinoma;ovarian epithelial tumour;tumour classification;

Podatki

Jezik: Angleški jezik
Leto izida:
Tipologija: 1.01 - Izvirni znanstveni članek
Organizacija: UL VF - Veterinarska fakulteta
UDK: 636.09:616
COBISS: 201195267 Povezava se bo odprla v novem oknu
ISSN: 1532-3129
Št. ogledov: 51
Št. prenosov: 5
Ocena: 0 (0 glasov)
Metapodatki: JSON JSON-RDF JSON-LD TURTLE N-TRIPLES XML RDFA MICRODATA DC-XML DC-RDF RDF

Ostali podatki

Sekundarne ključne besede: Pathology;Neoplasms;Dogs;
Vrsta dela (COBISS): Članek v reviji
Strani: str. 42-50
Zvezek: ǂVol. ǂ212
Čas izdaje: 2024
DOI: 10.1016/j.jcpa.2024.05.006
ID: 24599388