Pretvorba sulfidov v sulfoksimine

diplomsko delo

Tjaša Stopar (Author), Marjan Jereb (Mentor)

Abstract

Pretvorba sulfidov v sulfoksimine je kemijski proces, kjer gre za pretvorbo sulfida (R-S-R) najprej v sulfoksid (R-SO-R) in nato v sulfoksimin (R-SO-NH-R). V organski sintezi je ta korak pomemben, saj omogoča pripravo spojin s sulfoksiminsko funkcionalno skupino, ki se uporabljajo v medicinski kemiji ali kot intermediati pri sintezi drugih kompleksnih organskih spojin. Pristopi k NH-sulfoksiminom temeljijo na večstopenjskih sintezah, ki se začnejo s sulfidi. Pri tem so na voljo strategije za selektiven N- ali O- prenos na žveplov atom, kar vodi do ustreznega sulfoksida ali sulfilimina. Gre predvsem za neposredno pripravo NH-sulfoksiminov z uporabo lahko dostopnih virov amonijaka v prisotnosti PhI(OAc)$_2$. V okviru svojega diplomskega dela sem se osredotočila na pretvorbe sulfidov v sulfoksimine, ki sem jih izvajala z amonijevim karbonatom v prisotnosti diacetoksi jodobenzena v metanolu, najprej v manjšem in nato v večjem merilu.

Keywords

sulfoksidi;sulfoksimini;zelene pretvorbe;diplomske naloge;

Data

Language:	Slovenian
Year of publishing:	2024
Typology:	2.11 - Undergraduate Thesis
Organization:	UL FKKT - Faculty of Chemistry and Chemical Technology
Publisher:	[T. Stopar]
UDC:	547.1(043.2)
COBISS:	208352003
Views:	62
Downloads:	11
Average score:	0 (0 votes)
Metadata:

Other data

Secondary language:	English
Secondary title:	Conversion of sulfides to sulfoximines
Secondary abstract:	The conversion of sulfides to sulfoximines is a chemical process that involves the transformation of a sulfide (R-S-R) first into a sulfoxide (R-SO-R) and then into a sulfoximine (R-SO-NH-R). In organic synthesis, this step is important because it allows the preparation of compounds with a sulfoximine functional group, which are used in medicinal chemistry or as intermediates in the synthesis of other complex organic compounds. Approaches to NH-sulfoximines are based on multi-step syntheses starting from sulfides. In this context, strategies are available for selective N- or O-transfer to the sulfur atom, leading to the corresponding sulfoxide or sulfilimide. This primarily involves directly preparing NH-sulfoximines using readily accessible ammonia sources in the presence of PhI(OAc)$_2$. In my thesis, I focused on converting sulfides to sulfoximines, which I carried out with ammonium carbonate in the presence of (diacetoxyiodo)benzene in methanol, first on a small scale and then on a larger scale.
Secondary keywords:	sulfide;sulfoxide;sulfoximine;green conversion;Organska sinteza (kemija);Sulfidi;Univerzitetna in visokošolska dela;
Type (COBISS):	Bachelor thesis/paper
Study programme:	1000374
Embargo end date (OpenAIRE):	1970-01-01
Thesis comment:	Univ. v Ljubljani, Fak. za kemijo in kemijsko tehnologijo, VSŠ Kemijska tehnologija
Pages:	1 spletni vir (1 datoteka PDF (22 str.))
ID:	24985048